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906352-61-2

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906352-61-2 Usage

General Description

2-[4-(chloromethyl)phenyl]-1,3-thiazole is a chemical compound with the molecular formula C10H8ClNS. It is a thiazole derivative, which is a five-membered heterocyclic ring containing sulfur and nitrogen atoms. The compound contains a chloromethyl group and a phenyl group attached to the thiazole ring. It is used in pharmaceutical research as a potential drug candidate for various therapeutics, including antibacterial and antifungal agents. Additionally, it has also been studied for its potential use in materials science, particularly in the development of organic electronic devices and sensors. Overall, 2-[4-(chloromethyl)phenyl]-1,3-thiazole is a versatile compound with a wide range of potential applications in the field of chemistry and pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 906352-61-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,6,3,5 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 906352-61:
(8*9)+(7*0)+(6*6)+(5*3)+(4*5)+(3*2)+(2*6)+(1*1)=162
162 % 10 = 2
So 906352-61-2 is a valid CAS Registry Number.

906352-61-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4-(chloromethyl)phenyl]-1,3-thiazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:906352-61-2 SDS

906352-61-2Relevant articles and documents

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Ang, Chee Wei,Tan, Lendl,Sykes, Melissa L.,Abugharbiyeh, Neda,Debnath, Anjan,Reid, Janet C.,West, Nicholas P.,Avery, Vicky M.,Cooper, Matthew A.,Blaskovich, Mark A. T.

, p. 15726 - 15751 (2020/12/02)

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

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