906371-83-3Relevant academic research and scientific papers
Efficient access to azaindoles and indoles
McLaughlin, Mark,Palucki, Michael,Davies, Ian W.
, p. 3307 - 3310 (2006)
An expedient, catalytic method for the synthesis of diverse azaindoles and indoles, starting from readily available and inexpensive starting materials, is described. Conditions were developed for effective reductive alkylation of electron-deficient o-chlo
Efficient access to cyclic ureas via Pd-catalyzed cyclization
McLaughlin, Mark,Palucki, Michael,Davies, Ian W.
, p. 3311 - 3314 (2007/10/03)
An efficient regioselective method for the preparation of structurally diverse imidazopyridinones and benzoimidazolones starting from readily available and economical starting materials is described. High-yielding reductive alkylation of electron-deficient o-haloarylamines followed by treatment with inexpensive N-chlorosulfonyl isocyanate afforded primary ureas in good overall yields. A Pd-catalyzed urea cyclization reaction furnished imidazopyridinones and benzoimidazolones in excellent yields. Overall, the developed chemistry provides rapid access to pharmaceutically important heterocyclic compounds with high efficiency.
