906374-58-1

Upstream product

• 906374-53-6 2-chloromethyl-4,6-dihydroxy-benzoic acid 1-methyl-but-3-enyl ester 
• 3188-13-4 ethyl chloromethyl ether 
• 378749-93-0 4-tert-butyldiphenylsiloxy-2-chloromethyl-6-hydroxybenzoic acid 
• 936913-81-4 4-(tert-butyl-diphenyl-silanyloxy)-2-chloromethyl-6-hydroxy-benzoic acid 1-methyl-but-3-enyl ester 
• 64584-92-5 (R)-pent-4-en-2-ol 
• 625-31-0 (S)-4-penten-2-ol 
• 480-64-8 orsellinic acid 

Downstream Products

• 906374-47-8 2,4-bis-ethoxymethoxy-6-[1-phenylselanyl-4-(3-vinyl-oxiranyl)-butyl]-benzoic acid 1-methyl-but-3-enyl ester 
• 906374-48-9 2-[4-(2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-1-phenylselanyl-butyl]-4,6-bis-ethoxymethoxy-benzoic acid 1-methyl-but-3-enyl ester 

Relevant academic research and scientific papers

Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold

(Chemical Equation Presented) On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM = ethoxymethyl.

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases

Pochonins A-F were recently characterized as six new members of the naturally occurring family of 14membered resorcylic acid lactones. As there are a high number of ATPase and kinase inhibitors among natural resorcylic lactones, a library based on the poc