90642-81-2

Basic information

• Product Name: 2-aMino-2-phenylpropan-1-ol
• Synonyms: 2-aMino-2-phenylpropan-1-ol;2-Amino-2-phenyl-propanol;b-Amino-b-methylbenzeneethanol;2-Amino-2-phenyl-1-propanol
• CAS NO: 90642-81-2
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 90642-81-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 293.6°Cat760mmHg
• Flash Point: 131.3°C
• Appearance: /
• Density: 1.073g/cm³
• Vapor Pressure: 0.000779mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 2-aMino-2-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-2-phenylpropan-1-ol(90642-81-2)
• EPA Substance Registry System: 2-aMino-2-phenylpropan-1-ol(90642-81-2)

Safety Data

• Hazardous Substances Data: 90642-81-2(Hazardous Substances Data)

Usage

General Description

2-Amino-2-phenylpropan-1-ol, also known as β-phenylisopropanolamine, is a chemical compound with the molecular formula C9H13NO. 2-aMino-2-phenylpropan-1-ol is a phenylpropanolamine, which is a group of psychoactive drugs with varying stimulant, depressant, and anti-inflammatory effects. Although it shares a similar structure to amphetamine, it lacks the same level of central nervous system activity. This chemical is commonly used as an important intermediate in the synthesis of various pharmaceuticals, especially drugs with anti-adrenergic activity. The basic secondary amine contained in 2-Amino-2-phenylpropan-1-ol is also particularly useful in organic synthesis due to its capability to act as a nucleophile or base.

InChI:InChI=1/C9H13NO/c1-9(10,7-11)8-5-3-2-4-6-8/h2-6,11H,7,10H2,1H3

Upstream product

• 4355-46-8 α-amino-α-methylphenylacetonitrile 
• 98-86-2 acetophenone 
• 4507-40-8 2-(benzyloxycarbonylamino)-2-phenylpropanoic acid 
• 20398-59-8 ethyl 2-amino-2-phenylpropanoate 
• 565-07-1 2-amino-2-phenylpropanoic acid 

Downstream Products

• 943780-50-5 benzyl N-(2-hydroxy-1-methyl-1-phenyl)ethylcarbamate 
• 1617545-95-5 2-(6-chloro-pyrazin-2-ylamino)-2-phenyl-propan-1-ol 
• 1617545-79-5 2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-phenyl-propan-1-ol 
• 1353226-56-8 C₉H₁₃NO₄S 
• 1335117-44-6 4-methyl-4-phenylthiazolidine-2-thione 
• 1043488-68-1 (RS)-4-methyl-4-phenyl-4,5-dihydrooxazol-2-ylamine 

Relevant articles and documents

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.

NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

Versatile synthesis of free and N-benzyloxycarbonyl-protected 2,2-disubstituted taurines

An effective and versatile method was developed to synthesize N-benzyloxycarbonyl-protected and free 2,2-disubstituted taurines. Several novel 2,2-disubstituted taurines, including aliphatic/aromatic and cyclic/acyclic derivatives, were obtained, which demonstrates the generality of this method. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.