90643-25-7Relevant academic research and scientific papers
anti selective dihydroxylation by the ketimine derivatives of the allylic amine in monosubstituted olefins
Oh, Joon Seok,Park, Doh Yeon,Song, Bu Sop,Bae, Jae Gwang,Yoon, Seung Woong,Kim, Young Gyu
, p. 7209 - 7212 (2002)
Transformation of the allylic amine of monosubstituted olefins into the aryl ketimine derivatives resulted in consistent higher anti diastereofacial selectivity in the osmium-catalyzed dihydroxylation reactions, compared to the selectivities obtained from commonly used allylic amino derivatives such as N-acyl, N-Boc or N,N-dibenzyl. The anti selectivity ranged from 3:1 to 7:1 in dry THF and the best was observed with the 3,3′-difluorobenzophenone ketimine derivative. Application of the ketimine group is also reported with the substrates of biological importance.
IMIDAZOPYRIDINE COMPOUNDS
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Paragraph 0371, (2014/04/03)
[Problem] An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. [Means for Solution] It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.
