906463-11-4

Basic information

• Product Name: 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one
• Synonyms: 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one
• CAS NO: 906463-11-4
• Molecular Weight: 483.579
• Mol File: 906463-11-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one(906463-11-4)
• EPA Substance Registry System: 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one(906463-11-4)

Safety Data

• Hazardous Substances Data: 906463-11-4(Hazardous Substances Data)

Upstream product

• 906463-07-8 2,4-dibromo-6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 444665-07-0 4,6-Dibromo-3-(bromomethyl)-2-(2-chlorophenyl)pyridine 
• 444664-42-0 4,6-dibromo-2-(2-chlorophenyl)-3-methylpyridine 
• 906463-06-7 2-(2-chloro-phenyl)-3-methyl-5-nitro-pyridine 
• 906463-15-8 6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 906463-09-0 1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea 
• 906463-08-9 [4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-(4-methoxy-benzyl)-amine 
• 906463-10-3 7-bromo-5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one 

Downstream Products

• 906463-12-5 4-[5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrido[4,3-d]pyrimidin-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 906463-13-6 5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-piperidin-4-yl-3,4-dihydro-1H-pyrido[4,3-d]pyrimidin-2-one 
• 906463-16-9 4-[5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrido[4,3-d]pyrimidin-7-yl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones

p38 inhibitors based on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-one and 3,4-dihydropyrido[4,3-d]pyrimidin-2-one platforms were synthesized and preliminary SAR explored. Among the pyrimido-pyrimidones the emergence of two sub-types of analogs-C7-amino-pyrimi