906463-94-3Relevant academic research and scientific papers
Skraup-Doebner-Von Miller quinoline synthesis revisited: Reversal of the regiochemistry for γ-aryl-β,γ-unsaturated α-ketoesters
Wu, Yan-Chao,Liu, Li,Li, Hui-Jing,Wang, Dong,Chen, Yong-Jun
, p. 6592 - 6595 (2006)
A reversal of the standard regiochemistry of the Skraup-Doebner-Von Miller quinoline synthesis was observed when anilines were condensed with γ-aryl-β,γ-unsaturated α-ketoesters in refluxing TFA. The reaction is proposed to involve 1,2-addition of the ani
