90649-54-0

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 124-40-3 dimethyl amine 

Downstream Products

• 98995-06-3 4-amino-2-chloro-N,N-dimethylbenzamide 
• 879222-62-5 3-chloro-4-((dimethylamino)methyl)aniline 

Relevant academic research and scientific papers

AMINOAMIDE COMPOUNDS

Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. The compounds modulate protein function of 1L-1β, IL-2, IL-6, TNF-α, CK1α, GSPT1, aiolos, ikaros or helios, or combinations thereof. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.

Copper-catalyzed amide bond formation from formamides and carboxylic acids

A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.

Thiazolopyridine kinase inhibitors

The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I):