90649-73-3

Upstream product

• 1470-94-6 5-hydroxy-2,3-dihydro-1H-indene 
• 5111-69-3 5-methoxyindane 
• 344308-95-8 3-(3-chloro-4-methoxyphenyl)propionyl chloride 
• 344305-70-0 5-chloro-6-methoxy-2,3-dihydro-1H-inden-1-one 
• 90919-01-0 6-Chlor-5-methoxy-indan 

Relevant academic research and scientific papers

Multicomponent multicatalyst reactions (MC)2R: One-pot synthesis of 3,4-dihydroquinolinones

A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.

Synthesis and antianxiety activity of (ω-piperazinylalkoxy)indan derivatives

A series of (ω-piperazinylalkoxyl)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systematically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-(4-[4-fluorophenyl)-1-piperazinyl]propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chloridazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.