90650-06-9

Usage

Industrial applications

Rubber accelerator, stabilizer for PVC, intermediate for the synthesis of pharmaceuticals and agrochemicals

Physical properties

Pale yellow solid, bitter taste, soluble in many organic solvents

Toxicity

Moderate acute toxicity

Health effects

Can cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 6582-42-9 1-(3,4-dichlorophenyl)propan-1-one 

Downstream Products

• 1225220-10-9 (Z)-N-(1-(3,4-dichlorophenyl)prop-1-enyl)acetamide 
• 847448-26-4 N-cyanomethyl-N-[1-(3,4-dichloro-phenyl)-propyl]-formamide 
• 871313-07-4 [1-(3,4-dichloro-phenyl)-propylamino]-acetonitrile 
• 40023-89-0 3,4-dichloro-α-ethylbenzenemethanamine 

Relevant academic research and scientific papers

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

2-Mercaptoimidazoles, a new class of potent CCR2 antagonists

We describe the synthesis and SAR of a new class of CCR2 antagonists based on a 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC50 values in the MCP-1 induced Ca