906658-35-3

Upstream product

• 906657-90-7 methyl 4-acetoxy-6-acetoxymethyl-5-benzyloxynicotinate 
• 906657-89-4 methyl 4-acetoxy-5-benzyloxy-6-methyl-1-oxynicotinate 
• 61160-18-7 3-benzyloxy-2-methyl-1H-pyridin-4-one 
• 61049-69-2 3-O-benzylmaltol 
• 100-39-0 benzyl bromide 
• 906657-88-3 methyl 4-acetoxy-5-benzyloxy-6-methylnicotinate 
• 1421314-65-9 5-benzyloxy-4-hydroxy-6-methyl-nicotinic acid methyl ester 
• 1421314-64-8 3-benzyloxy-5-bromo-2-methyl-pyridin-4-ol 
• 118-71-8 Maltol 
• 1421314-65-9 methyl 5-benzyloxy-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylate 
• 1421314-64-8 3-(benzyloxy)-5-bromo-2-methylpyridin-4(1H)-one 

Downstream Products

• 906657-92-9 5-benzyloxy-N-(4-fluoro-benzyl)-4-hydroxy-6-hydroxymethyl-nicotinamide 
• 906657-93-0 C₂₇H₂₂FN₅O₄ 
• 1421314-67-1 5-benzyloxy-N-(4-fluoro-benzyl)-6-formyl-4-hydroxy-nicotinamide 
• 906657-95-2 3-benzyloxy-5-(4-fluoro-benzylcarbamoyl)-4-hydroxy-pyridine-2-carboxylic acid 
• 1421314-68-2 3-benzyloxy-5-(4-fluoro-benzylcarbamoyl)-4-hydroxy-pyridine-2-carboxylic acid methyl ester 
• 906657-98-5 methyl 3-(benzyloxy)-5-((4-fluorobengzyl)carbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate 
• 906657-97-4 methyl 1-allyl-3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate 
• 906657-99-6 9-benzyloxy-2-(2-methoxyethyl)-1,8-dioxo-1,8-dihydro-2H-pyrid[1,2-a]pyrazine-7-carboxylic acid 4-fluorobenzylamide 
• 1421314-66-0 5-benzyloxy-N-(4-fluorobenzyl)-6-hydroxymethyl-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 906657-95-2 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 
• 1421314-68-2 methyl 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate 
• 906658-01-3 9-benzyloxy-2-[2-(morpholin-4-yl)ethyl]-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 4-fluorobenzylamide 
• 906658-04-6 9-benzyloxy-2-(2-isopropoxyethyl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 4-fluorobenzylamide 
• 906658-22-8 9-benzyloxy-1,8-dioxo-2-(2-phenoxyethyl)-1,8-dihydro-2Hpyrido[1,2-a]pyrazine-7-carboxylic acid 4-fluorobenzylamide 

Relevant academic research and scientific papers

Carbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles

This work is a continuation of our initial discovery of a potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor that displayed favorable antiviral and pharmacokinetic properties. We report herein a series of

POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.