906749-05-1

Basic information

• Product Name: N-benzoyl-2'-deoxy-8-methyladenosine
• CAS NO: 906749-05-1
• Molecular Weight: 369.38
• Mol File: 906749-05-1.mol

Chemical Properties

• CAS DataBase Reference: N-benzoyl-2'-deoxy-8-methyladenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-2'-deoxy-8-methyladenosine(906749-05-1)
• EPA Substance Registry System: N-benzoyl-2'-deoxy-8-methyladenosine(906749-05-1)

Safety Data

• Hazardous Substances Data: 906749-05-1(Hazardous Substances Data)

Upstream product

• 906749-04-0 8-Methyl-9-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 906749-06-2 N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-8-methyl-9H-purin-6-yl)-benzamide 

Relevant articles and documents

Effects of 8-methyl-2′-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides

In this paper we report the synthesis and the structural characterization of two modified oligodeoxyribonucleotides (ODNs), namely d(A8MeGGGT) and d(TA8MeGGGT), where A8Me represents a 8-methyl-2′-deoxyadenosine. Both ODNs have been studied by 1H NMR, CD spectroscopy and molecular modelling and shown to form fourfolds symmetric G-quadruplex structures, with all strands parallel and equivalent to each other. The complexes are characterized by thermal stabilities comparable to that of their natural counterparts. NOE patterns involving 8-methyl group in A8Me residues allowed us to define the main structural features at the 5′-end of the complexes. Particularly, inter- and intrastrand NOEs show a syn-orientation and a symmetrical arrangement of A8Me bases stacking on the adjacent G-tetrad.