906820-53-9Relevant academic research and scientific papers
Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives
Nigade, Ganesh,Chavan, Pradeep,Deodhar, Meenakshi
experimental part, p. 27 - 37 (2012/06/01)
A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)- 4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2- Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist. Springer Science+Business Media, LLC 2010.
Thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives of isonicotinic acid hydrazide: Synthesis and their biological evaluation
Gilani, Sadaf J.,Khan, Suroor A.,Alam, Ozair,Singh, Vijender,Arora, Alka
, p. 1057 - 1067 (2012/02/05)
A series of thiazolidin-4-one (2a-h; 3a-h), azetidin-2-one (4a-h) and 1,3,4-oxadiazole (5a-h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and
