906820-54-0

Basic information

• Product Name: 2-(2,4-dichlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole
• CAS NO: 906820-54-0
• Molecular Weight: 336.177
• Mol File: 906820-54-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,4-dichlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dichlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(906820-54-0)
• EPA Substance Registry System: 2-(2,4-dichlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(906820-54-0)

Safety Data

• Hazardous Substances Data: 906820-54-0(Hazardous Substances Data)

Upstream product

• 144293-91-4 C₁₃H₉Cl₂N₃O 
• 108-24-7 acetic anhydride 
• 54-85-3 isoniazid 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 183368-62-9 2-(2,4-dichlorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazole 

Relevant articles and documents

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.