90696-41-6

Upstream product

• 2975-46-4 3-(trimethylsilyl)prop-2-yn-1-al 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 90696-30-3 cis-4-ethynyl-3-isopropyl-1-(p-methoxyphenyl)-2-azetidinone 
• 90696-29-0 cis-3-isopropyl-1-(p-methoxyphenyl)-4-((trimethylsilyl)ethynyl)-2-azetidinone 
• 90696-32-5 trans-3-isopropyl-1-(p-methoxyphenyl)-4-((trimethylsilyl)ethynyl)-2-azetidinone 
• 929611-76-7 C₁₈H₂₀N₂O₂ 
• 929611-73-4 C₁₆H₁₆N₂O₂ 

Relevant academic research and scientific papers

Novel 2-pyridone synthesis via nucleophilic addition of malonic esters to alkynyl imines

(Matrix presented) A novel 2-pyridone synthesis via nucleophilic addition of malonic esters to alkynyl imines has been developed. The reaction of dialkylalkyl sodiomalonates with alkynyl imines provided 2-pyridones in good to excellent yields.

STEREOSELECTIVE SYNTHESIS OF cis- AND trans-3-DIBENZYLAMINO-β-LACTAMS

Depending on reaction conditions, both cis- and trans-3-dibenzylamino-β-lactams have been synthesised stereoselectively through condensation of imines with the lithium enolate of ethyl dibenzylaminoacetate, 1.

N-Trimethylsilyl Imines: Applications to the Synthesis of β-Lactams

Ester enolates and N-trimethylsilyl imines react to afford N-protio-β-lactams.The stereochemical course of the reaction depends on the ester enolate geometry.Therefore (E)-enolates give mainly cis β-lactams while (Z)-enolates give nearly equal mixtures of cis and trans β-lactams.The use of ethyl β-hydroxybutyrate as the ester component allows the preparation of β-lactams of potential use in carbapenem synthesis.The differences in the behavior of N-trimethylsilyl and N-aryl imines in ester-imine condensations are also discussed.