90714-07-1Relevant academic research and scientific papers
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications
Ottanà, Rosaria,MacCari, Rosanna,Giglio, Marco,Del Corso, Antonella,Cappiello, Mario,Mura, Umberto,Cosconati, Sandro,Marinelli, Luciana,Novellino, Ettore,Sartini, Stefania,La Motta, Concettina,Da Settimo, Federico
experimental part, p. 2797 - 2806 (2011/07/08)
In continuing the search for more effective 5-arylidene-4-thiazolidinones as aldose reductase inhibitors, a new set of suitably substituted compounds (4, 5 and 8) was explored. Acetic acids 5, particularly 5a and 5h, proved to be interesting inhibitors of the enzyme as well as excellent antioxidant agents that are potentially able to counteract the oxidative stress associated with both diabetic complications as well as other pathologies. Molecular docking experiments supported SAR studies.
79Br NMR spectroscopy as a practical tool for kinetic analysis
Chan, Si Jia,Howe, Andrew G.,Hook, James M.,Harper, Jason B.
experimental part, p. 342 - 347 (2010/02/27)
79Br NMR spectroscopy has been used to monitor a series of reactions in which the bromide ion is produced, including the Menschutkin reaction of pyridine with a range of substituted benzyl bromides and a Heck coupling process. In cases where the process could also be monitored using 1H NMR spectroscopy, the kinetic analyses using heteronuclear magnetic resonance spectroscopy were shown to be completely consistent. Both the utility of the process in following reactions which may be difficult to analyse using other techniques and the practical limitations associated with solvent choice are discussed. Copyright
ACID-CATALYZED ISOMERIZATION OF 1-FORMYL-2,2-DIPHENYLTHIOCYCLOPROPANES TO 2,2-DIPHENYLTHIO-2,3-DIHYDROFURANS. A CONVENIENT METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-PHENYLTHIOFURANS
Kulinkovich, O. G.,Tishchenko, I. G.,Roslik, N. A.
, p. 480 - 484 (2007/10/02)
In the presence of catalytic amounts of p-toluenesulfonic acid in methylene chloride trans-3-aryl(methyl)-2,2-phenylthio-1-formylcyclopropanes readily isomerize to the corresponding 2,2-diphenylthio-2,3-dihydrofurans.The latter are converted by the action
