907185-72-2Relevant academic research and scientific papers
Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders
De Nanteuil, Guillaume,Gloanec, Philippe,Béguin, Suzette,Giesen, Peter L. A.,Hemker, H. Coenraad,Mennecier, Philippe,Rupin, Alain,Verbeuren, Tony J.
, p. 5047 - 5050 (2007/10/03)
The synthesis and evaluation of inhibitors of activated protein C (aPC) are reported. This serine protease is partly responsible for the degradation of factor Villa, involved in the regulation of bleeding in hemophilia A. Benzamidine-containing derivatives were found to be potent aPC inhibitors, some of them showing selectivity against the procoagulant protease thrombin. Moreover, compound 1 significantly restored the generation of thrombin in hemophiliac plasma.
Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
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Page/Page column 5, (2008/06/13)
Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 wherein R6, R7, R8 an
