907190-75-4Relevant academic research and scientific papers
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Pinkerton, Anthony B.,Huang, Dehua,Cube, Rowena V.,Hutchinson, John H.,Struthers, Mary,Ayala, Julia M.,Vicario, Pasquale P.,Patel, Sima R.,Wisniewski, Thomas,DeMartino, Julie A.,Vernier, Jean-Michel
, p. 807 - 813 (2007/10/03)
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50/sub
SUBSTITUTED PYRAZOLES AS MODULATORS OF CHEMOKINE RECEPTORS
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Page/Page column 33, (2008/06/13)
Substituted pyrazole compounds such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including al
