907218-68-2Relevant academic research and scientific papers
In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3- carbonitriles as JAK2 kinase inhibitors
Wang, Tao,Ioannidis, Stephanos,Almeida, Lynsie,Block, Michael H.,Davies, Audrey M.,Lamb, Michelle L.,Scott, David A.,Su, Mei,Zhang, Hai-Jun,Alimzhanov, Marat,Bebernitz, Geraldine,Bell, Kirsten,Zinda, Michael
, p. 2958 - 2961 (2011)
Synthesis and biological evaluation of a series of 6-aminopyrazolyl- pyridine-3-carbonitriles as JAK2 kinase inhibitors was reported. Biochemical screening, followed by profile optimization, resulted in JAK2 inhibitors exhibiting good kinase selectivity, pharmacokinetic properties, physical properties and pharmacodynamic effects.
