90731-99-0 Usage
Uses
Used in Pharmaceutical Industry:
3-Chloro-4-isopropylpyridine is utilized as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones. Its unique structure allows for the creation of diverse chemical entities with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-chloro-4-isopropylpyridine is employed as an intermediate for the synthesis of pesticides and other crop protection products. Its incorporation aids in the development of more effective and targeted pest control solutions.
Used in Organic Synthesis Research:
3-Chloro-4-isopropylpyridine is a vital component in organic synthesis research, where it is used to explore novel reactions and develop new synthetic pathways. Its presence in the literature as a potential key intermediate highlights its importance in advancing the field of organic chemistry.
Used in the Synthesis of Novel Bioactive Molecules:
3-Chloro-4-isopropylpyridine has been reported as a potential key intermediate in the synthesis of novel bioactive molecules. This application underscores its versatility and the potential for discovering new compounds with significant biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 90731-99-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,7,3 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90731-99:
(7*9)+(6*0)+(5*7)+(4*3)+(3*1)+(2*9)+(1*9)=140
140 % 10 = 0
So 90731-99-0 is a valid CAS Registry Number.
90731-99-0Relevant academic research and scientific papers
Transition-metal-free BF3-mediated regioselective direct alkylation and arylation of functionalized pyridines using grignard or organozinc reagents
Chen, Quan,Du Jourdin, Xavier Mollat,Knochel, Paul
supporting information, p. 4958 - 4961 (2013/05/22)
A formal regioselective cross-coupling of various pyridines with alkyl and aryl groups can be achieved by a BF3·OEt2-mediated addition of Grignard or organozinc reagents to pyridines bearing various substituents (chloro, bromo, cyano, vinyl, phenyl, carbethoxy, nitro, etc.) followed by an oxidative aromatization mediated by chloranil. Good regioselectivity and wide functional group tolerance make this method very versatile for the preparation of polyfunctional pyridines. No transition-metal catalyst is required in these coupling reactions.
SYNTHESIS OF 3-HALO- AND 3-FORMYL-4-ALKYLPYRIDINES
Comins, Daniel L.,Smith, Roy K.,Stroud, Eric D.
, p. 339 - 344 (2007/10/02)
In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-halopyridines gives 4-alkyl-3-halo-1-phenoxycarbonyl-1,4-dihydropyridines.The crude dihydropyridines were aromatized with o-chloroanil to give 4-alkyl-3-halopyridines.Several 4-alkylnicotinaldehydes were synthesized in a similar manner from the cyclic acetal (1,3-dioxolane) of 3-pyridinecarboxaldehyde.After aromatization with sulfur, the crude acetals were hydrolyzed with oxalic acid to give the desired pyridinecarboxaldehydes.
