90732-29-9

Usage

Heterocyclic compound

1H-Indole, 1-(2,2,2-trifluoroethyl)belongs to the class of heterocyclic compounds known as indoles.

1H-indole core

The compound is characterized by a 1H-indole core.

Substitution

The 1H-indole core is substituted at position 1 with a 2,2,2-trifluoroethyl group.

Pharmaceutical industry use

1H-Indole, 1-(2,2,2-trifluoroethyl)is commonly used in the pharmaceutical industry for the synthesis of various biologically active compounds and drug molecules.

Unique structure

The unique structure and properties of 1H-Indole, 1-(2,2,2-trifluoroethyl)make it a valuable building block for the development of novel pharmaceuticals and agrochemicals.

Organic synthesis and medicinal chemistry research

The compound has potential applications in organic synthesis and medicinal chemistry research due to its ability to modulate biological activities in chemical reactions.

Upstream product

• 120-72-9 indole 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 54813-79-5 N-(2,2,2-trifluoroethyl)indoline 

Relevant academic research and scientific papers

AMINOPYRIMIDINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, for treating various cancer described herein, such as lung cancer (e.g., non-small cell lung cancer).

Pyrimidine heterocyclic compounds, preparation method and application thereof

The present invention relates to compounds of a formula (I) shown in the description, and pharmaceutically acceptable salts, prodrugs and solvates thereof, and the compounds are useful for treating cancer and inflammation in mammals. The invention also discloses a preparation method for the compounds of the formula (I) and a pharmaceutical composition containing the compound.

ON THE REACTION OF INDOLE WITH SODIUM BOROHYDRIDE IN TRIFLUOROACETIC ACID

The reaction of indole (1) with sodium borohydride in trifluoroacetic acid gives, successively, indoline (3), N-(2,2,2-trifluoroethyl)indoline (4), and 1,1,1-trifluoro-2,2-bisethane (5), whose structure is established by chemical and spectral means.Similar reactions are observed with N-methylaniline (8) and anisole, but not with dibenzazepines 13 and 15, which give only N-trifluoroethylation.