90754-64-6Relevant academic research and scientific papers
Development of high-load, soluble oligomeric sulfonate esters via ROM polymerization: Application to the benzylation of amines
Zhang, Mianji,Moore, Joel D.,Flynn, Daniel L.,Hanson, Paul R.
, p. 2657 - 2660 (2004)
The development of high-load, soluble oligomeric sulfonate esters, generated via ROM polymerization, and their utility in the facile benzylation of an array of amines is reported. These polymeric sulfonate esters exist as free-flowing powders, are stable
Base-promoted N-alkylation using formamides as the N-sources in neat water
Chen, Wen-Xin,Zhang, Cai-Yun,Shao, Li-Xiong
, p. 880 - 885 (2014/01/23)
An efficient catalyst-free, alternative method for the C-N bond formation reaction of alkyl electrophiles using formamides as the N-sources was achieved under mild conditions. The reaction possesses the advantages of a broad range of substrates scope and wide functional group tolerance. It should also be noted that this process was performed using the environmentally benign water as the sole solvent, and high yield can also be achieved in ten-gram scale.
Highly efficient amination in neat water of benzyl chlorides with dialkylformamides catalysed by N-heterocyclic carbene-palladium(II)-1- methylimidazole complex
Chen, Wen-Xin,Zhang, Cai-Yun,Lu, Jian-Mei
, p. 611 - 614 (2013/11/06)
Dialkylformamides are excellent N-sources in the amination of benzyl chlorides when catalysed by a NHC-Pd(II)-Im complex. In the presence of NaOH and the catalyst, variously substituted benzyl chlorides and five different dialkylformamides reacted smoothly to afford the corresponding N,N-dialkyl-benzylamines in good to almost quantitative yields in eco-friendly solvent water at 50 °C within 3 h.
N-2-hydroxyethyl N'-alkylpiperazines and benzylamines: Chemistry and pharmacology
Scotto di Tella,Dessaigne,Boyer,et al.
, p. 131 - 135 (2007/10/02)
The authors have prepared some benzylamine derivatives and established a structure-antidysrhythmic activity relationship. Most of the compounds exhibited significant activity. One also showed interesting anticalcium activity.
