90754-68-0Relevant academic research and scientific papers
Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl disiloxane (DPDS)
Aldrich, Courtney C.,Hammerstad, Travis A.,Hegde, Pooja V.,Wang, Kathleen J.
, (2022/02/10)
A convenient procedure for the chemoselective reduction of tertiary amides at room temperature in the presence of air and moisture using 1,3-diphenyldisiloxane (DPDS) is developed. The reaction conditions tolerate a significant number of functional groups including esters, nitriles, secondary amides, carbamates, sulfoxides, sulfones, sulfonyl fluorides, halogens, aryl-nitro groups, and arylamines. The conditions reported are the mildest to date and utilize EtOAc, a preferred solvent given its excellent safety profile and lower environmental impact. The ease of setup and broad chemoselectivity make this method attractive for organic synthesis, and the results further demonstrate the utility of DPDS as a selective reducing agent.
Use of (cyclopentadienone)iron tricarbonyl complexes for c-n bond formation reactions between amines and alcohols
Brown, Thomas J.,Cumbes, Madeleine,Diorazio, Louis J.,Clarkson, Guy J.,Wills, Martin
, p. 10489 - 10503 (2018/05/31)
The application of a series of (cyclopentadienone)iron tricarbonyl complexes to "borrowing hydrogen" reactions between amines and alcohols was completed in order to assess their catalytic activity. The electronic variation of the aromatic groups flanking the C?O of the cyclopentadienone influenced the efficiency of the reactions; however, in other cases, the Kn?lker catalyst 1, containing trimethylsilyl groups flanking the cyclopentadienone ketone, gave the best results. In some cases, the change of the ratio of amine to alcohol improves the conversion significantly. The application of iron catalysts to the synthesis of a range of amines, including unsaturated amines, was investigated.
Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines
Tan, Peng Wen,Haughey, Maxwell,Dixon, Darren J.
supporting information, p. 4406 - 4409 (2015/03/18)
PdII-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C-H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield. This journal is
An expedient three-component synthesis of tertiary benzylamines
Le Gall, Erwan,Decompte, Alexandre,Martens, Thierry,Troupel, Michel
experimental part, p. 249 - 254 (2010/04/05)
A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines. Georg Thieme Verlag Stuttgart.
N-2-hydroxyethyl N'-alkylpiperazines and benzylamines: Chemistry and pharmacology
Scotto di Tella,Dessaigne,Boyer,et al.
, p. 131 - 135 (2007/10/02)
The authors have prepared some benzylamine derivatives and established a structure-antidysrhythmic activity relationship. Most of the compounds exhibited significant activity. One also showed interesting anticalcium activity.
