907584-59-2

Upstream product

• 113642-11-8 methyl m-bromo-p-<1-hydroxy-2-(4-oxoazetidin-2-yl)ethyl>benzoate 
• 907584-56-9 benzyl m-bromo-p-<1-hydroxy-2-(4-oxoazetidin-2-yl)ethyl>benzoate 
• 86951-27-1 methyl m-bromo-p-<(4-oxoazetidin-2-yl)acetyl>benzoate 
• 113641-97-7 3-Bromo-4-(1-trimethylsilanyloxy-vinyl)-benzoic acid methyl ester 
• 113642-06-1 methyl p-acetyl-m-bromobenzoate 
• 113642-05-0 methyl m-bromo-p-ethylbenzoate 
• 99548-53-5 3-Bromo-4-ethylbenzoic acid 

Downstream Products

• 113655-82-6 benzyl 2-chlorobenzocarbacephem-4'-carboxylate 

Relevant academic research and scientific papers

Active-copper-promoted expeditious N-arylations in aqueous media under microwave irradiation

Active-copper-promoted mild and expeditious N-arylations of amines, amides, imides, and β-lactams with aryl halides under microwave irradiation conditions are reported. These reactions can be performed at 85-90 °C in aqueous media as well as under solvent-free conditions to give good yields. However, under solvent-free conditions, lower yields are obtained. Georg Thieme Verlag Stuttgart.

Synthesis of Benzocarbacephem and Benzocarbapenem Derivatives by Copper-promoted Intramolecular Aromatic Substitution

Copper-mediated cyclisation of 4-azetidinones and 4-azetidinones proved to be a route to benzocarbacephem and benzocarbapenem derivatives respectively.The effect of functionalities present in the alkyl part of the ring to be formed was considered with regard to cyclisation efficiency and further chemical modifications.Conversion, into halide, of the diastereoisomeric mixture (4R,6S; 4S,6R; 4R,6R; and 4S,6S) of t-butyl 2-hydroxybenzocarbacephem-4'-carboxylate (14f) afforded either the chloride (17a) as racemic diastereoisomers or the fluoride (17c) as a single racemic diastereoisomer.The corresponding free carboxylic acids (18a, c) were designed as inactivators of beta-lactamases.