113642-06-1

Upstream product

• 113642-05-0 methyl m-bromo-p-ethylbenzoate 
• 113642-07-2 2-bromo-4-carboxyacetophenone 
• 74-88-4 methyl iodide 
• 99548-53-5 3-Bromo-4-ethylbenzoic acid 

Downstream Products

• 113641-97-7 3-Bromo-4-(1-trimethylsilanyloxy-vinyl)-benzoic acid methyl ester 
• 86951-27-1 methyl m-bromo-p-<(4-oxoazetidin-2-yl)acetyl>benzoate 
• 113642-11-8 methyl m-bromo-p-<1-hydroxy-2-(4-oxoazetidin-2-yl)ethyl>benzoate 
• 907584-59-2 benzyl 2-hydroxybenzocarbacephem.-4'-carboxylate 
• 113655-82-6 benzyl 2-chlorobenzocarbacephem-4'-carboxylate 
• 1101881-95-1 methyl 3-bromo-4-(1-hydroxy-ethyl)benzoate 
• 1383604-64-5 methyl 3-bromo-4-[3-(dimethylamino)acryloyl]benzoate 
• 1383604-66-7 methyl 4-(1-benzyl-1H-pyrazol-5-yl)-3-ethynylbenzoate 
• 1383604-67-8 methyl 4-(1-benzyl-1H-pyrazol-5-yl)-3-[(trimethylsilyl)ethynyl]benzoate 
• 1383604-65-6 methyl 4-(1-benzyl-1H-pyrazol-5-yl)-3-bromobenzoate 

Relevant academic research and scientific papers

NOVEL AROMATIC COMPOUND AND USE THEREOF

Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or To treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

Atroposelective radical aryl migration reactions from sulfur to carbon

The paper describes stereoselective radical aryl migration reactions from sulfur in sulfonates to aryl radicals for the synthesis of axially chiral biaryls. A chirality center in secondary benzylic sulfonates is used to diastereoselectively (atroposelectively) install a stereogenic axis via a 1,5 aryl migration reaction. Atroposelectivity has not been investigated in stereoselective radical chemistry before. Good yields (53-82%) but low selectivities (up to 2 to 1) were obtained.

Synthesis of Benzocarbacephem and Benzocarbapenem Derivatives by Copper-promoted Intramolecular Aromatic Substitution

Copper-mediated cyclisation of 4-azetidinones and 4-azetidinones proved to be a route to benzocarbacephem and benzocarbapenem derivatives respectively.The effect of functionalities present in the alkyl part of the ring to be formed was considered with regard to cyclisation efficiency and further chemical modifications.Conversion, into halide, of the diastereoisomeric mixture (4R,6S; 4S,6R; 4R,6R; and 4S,6S) of t-butyl 2-hydroxybenzocarbacephem-4'-carboxylate (14f) afforded either the chloride (17a) as racemic diastereoisomers or the fluoride (17c) as a single racemic diastereoisomer.The corresponding free carboxylic acids (18a, c) were designed as inactivators of beta-lactamases.