90760-69-3Relevant academic research and scientific papers
Srereoselective Synthesis of Alcohols, XXIII Transfer of Chirality on Addition of (α-Chloroallyl)boronates to Aldehydes
Hoffmann, Reinhard W.,Landmann, Bernd
, p. 2013 - 2024 (2007/10/02)
The preparation of the (α-chloroallyl)boronate 4 of 92percent e.e. is described.Its addition toachiral aldehydes resulted in the homoallyl alcohols 6 of 82-92percent e.e.Cooperative diastereoface selectivity on addition of ent-4 to isopropylideneglyceraldehyde (22) gave the product 23 of high diastereomeric purity.Reagent control of stereoselectivity on addition of 4 to 22 resulted in 25 in 77percent diastereomeric purity.
