90764-86-6

Upstream product

• 55289-35-5 2-bromo-6-nitrotoluene 
• 88-72-2 1-methyl-2-nitrobenzene 
• 124-63-0 methanesulfonyl chloride 
• 603-83-8 3-nitro-o-tolylamine 
• 2666-57-1 2-Methyl-3-nitro-phenyl-thiocyanat 
• 82173-72-6 2-nitro-6-(methylthio)toluene 

Relevant academic research and scientific papers

Preparation method of 2-nitro-4-methylsulphonyl methylbenzene

The invention discloses a preparation method of 2-nitro-4-methylsulphonyl methylbenzene. The preparation method includes: in presence of a catalyst, enabling o-nitrosotoluene to react with methylsulphonyl chloride, wherein the catalyst is quaternary ammonium salt type ion liquid loaded on an orderly mesoporous material. The quaternary ammonium salt type ion liquid catalyst catalyzes reaction of o-nitrosotoluene and methylsulphonyl chloride in the orderly mesoporous material, ortho-position thiamphenicol reaction is limited, para-position thiamphenicol reaction is promoted, and the preparation method is high in selectivity and yield and relatively low in synthesis cost.

INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS

Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.