90765-02-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Acetamido-5-nitro-4-picoline is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity allow it to be incorporated into the development of new drugs, potentially leading to innovative treatments for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-acetamido-5-nitro-4-picoline serves as a key component in the production of certain pesticides and other agricultural chemicals. Its properties enable it to be integrated into formulations that can effectively control pests and diseases in crops, thereby contributing to increased agricultural productivity.
Used in Organic Synthesis:
2-Acetamido-5-nitro-4-picoline is also utilized in the field of organic synthesis, where it can participate in a wide range of chemical reactions. Its versatility allows it to be used as a building block for the creation of various organic compounds, which can be further applied in different industries, such as the development of new materials, dyes, and other specialty chemicals.
Used in Research and Development:
The potential biological activities of 2-acetamido-5-nitro-4-picoline make it a subject of interest for researchers in the field of medicinal chemistry. Its study could lead to the discovery of new therapeutic agents or provide insights into the mechanisms of existing drugs, ultimately contributing to advancements in medical science.

InChI:InChI=1/C8H9N3O3/c1-5-3-8(10-6(2)12)9-4-7(5)11(13)14/h3-4H,1-2H3,(H,9,10,12)

Upstream product

• 21901-40-6 2-amino-5-nitro-4-picoline 
• 108-24-7 acetic anhydride 

Downstream Products

• 174610-12-9 1H-pyrrolo[2,3-c]pyridin-5-amine 
• 174610-11-8 N-(1H-pyrrolo[2,3-c]pyridin-5-yl)acetamide 
• 475060-22-1 tert-butyl N-(5-fluoro-4-methyl-pyridin-2-yl)carbamate 
• 475060-21-0 N₁-(5-fluoro-4-methyl-pyridin-2-yl)acetamide 
• 301222-66-2 2-amino-5-fluoro-4-methylpyridine 
• 475060-18-5 N₁-(5-amino-4-methyl-pyridin-2-yl)acetamide 

Relevant academic research and scientific papers

Indole-2-ketone derivative, preparation method and application thereof

The invention belongs to the field of medicines, particularly relates to an indole-2-ketone derivative, a preparation method and application thereof, and provides a compound represented by the following formula (I), a stereoisomer, a racemate, a tautomer,

HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Exchange of the ethylene tether in a series of pyridopyrimidine-based MexAB-OprM specific efflux pump inhibitors to an amide bond stabilized the olefin of the acrylic acid moiety, preventing facile photoisomerization to the Z-isomer. Furthermore, the activity was drastically improved in the amide tether variants, providing extremely potent acrylic acid and vinyl tetrazole analogues.

Drug efflux pump inhibitor

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)— (R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.