90770-94-8Relevant academic research and scientific papers
Deriving agent based on isoquinoline structure and preparation method and application thereof
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Paragraph 0055; 0057, (2021/07/08)
The invention provides a deriving agent based on an isoquinoline structure. The structure of the deriving agent is represented by a formula (I). The invention also provides a preparation method of the deriving agent based on the isoquinoline structure. The deriving agent based on the isoquinoline structure can be used for deriving compounds containing functional groups such as carboxyl, amido, aldehyde group and keto group, the mass spectrum response intensity of the derived compounds is improved, and the chromatographic retention of the derived compounds is improved. The invention further provides a method for deriving a compound containing functional groups such as carboxyl, amido, aldehyde group and keto group by using the deriving agent. The deriving reaction of the deriving agent is simple to operate and mild in reaction condition, the deriving reaction can be completed within 1 hour at room temperature, the deriving efficiency is greatly improved, the derived product can generate the same fragment ions under the same collision energy, so that the establishment of a subsequent mass spectrometric detection method is facilitated. Meanwhile, the isotope labeled deriving agent is simple to synthesize, internal standard method quantification can be realized, and the accuracy of a quantification result is improved.
