90776-76-4Relevant academic research and scientific papers
CONDENSATION DU CYANOACETATE D'ETHYLE SODE SUR LES SELS D'IMINOETHERS CYCLIQUES. SYNTHESE DIRECTE DE DERIVES D'OXAZEPINE-1,4 ONE-7
Dreme, M.,Brunel, S.,Llauro, M. F.,Perchec, P. Le,Garapon, J.,Sillion, B.
, p. 349 - 354 (2007/10/02)
Sodium ethylcyanoacetate was found to react exclusively at the 2-position of trifluormethanesulfonate 2-alkyl(aryl) 1,3-oxazolinium salts 2.In most cases, the reaction leads specifically to a new series of 5-alkyl(aryl) 6-cyano 2,3-dihydro 1,4-oxazepine 7-ones 3.This efficient one-step ring-enlargement process occurs at the oxazolidin stage.Structural parameters affecting the scope and limitations of this condensation are discussed.
