90784-41-1Relevant academic research and scientific papers
N-Heterocyclic Carbene-Catalyzed Synthesis of α-Trifluoromethyl Esters
Gelat, Fabien,Patra, Atanu,Pannecoucke, Xavier,Biju, Akkattu T.,Poisson, Thomas,Besset, Tatiana
, p. 3897 - 3901 (2018/07/22)
The N-heterocyclic carbene (NHC)-catalyzed trifluoromethylation of α-chloro aldehydes was developed, allowing straightforward access to valuable α-trifluoromethyl ester derivatives. The unique combination of an electrophilic trifluoromethylation reagent with NHC catalysis was the key for the functionalization of a broad range of α-chloro aldehydes, and the products are formed in moderate to good yields. Investigations of the enantioselective version of this reaction afforded the enantioenriched products in moderate yields with good ee values.
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3: The important role of water as a promoter
Hu, Mingyou,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 15257 - 15260 (2012/10/29)
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3 reagent has been developed as a new method to prepare α-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from CuI/TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.
Preparation of α-Trifluoromethyl Esters from Malonic Esters
Everett, Stephen T.,Purrington, Suzanne T.,Bumgardner, Carl L.
, p. 3702 - 3706 (2007/10/02)
A wide variety of α-trifluoromethyl esters can be synthesized in two steps starting from monosubstituted malonic esters and dibromodifluoromethane.The product of the first step, a bromodifluoromethyl-substituted malonate, is transformed to the desired fin
PREPARATION OF ESTERS CONTAINING AN Α-CF3 GROUP
Purrington, Suzanne, T.,Everett, T. Stephen,Bumgardner, Carl L.
, p. 1329 - 1332 (2007/10/02)
Malonates may be converted to esters containing an α-CF3 group in a two-step process involving bromodifluoromethylation of the malonates followed by decarboxyalkylation-fluorination with fluoride ion in DMSO.
