90793-64-9

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(2,6-dichlorophenyl)acetate is utilized as a key intermediate in the synthesis of heteroarylaminonaphthyridinone derivatives. These derivatives are of significant interest due to their application as multiple kinase pathway inhibitors, which are crucial in the development of targeted therapies for various diseases, including cancer and other proliferative disorders.
The use of ethyl 2-(2,6-dichlorophenyl)acetate in this context highlights its importance in medicinal chemistry, where it contributes to the creation of novel and effective treatments by modulating the activity of specific kinase pathways. This application underscores the compound's role in advancing the field of drug discovery and development.

Upstream product

• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 118-69-4 2,6-dichlorotoluene 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 

Downstream Products

• 129564-34-7 2-(2,6-dichlorophenyl)acetohydrazide 
• 1201836-77-2 [2-(2,6-dichloro-benzyl)-pyrrolidin-1-yl]-(3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-methanone 
• 383127-93-3 2-(2,6-dichloro-benzyl)-pyrrolidine 
• 1201837-06-0 5-(2,6-dichloro-benzyl)-3,4-dihydro-2H-pyrrole 
• 1588423-83-9 7-chloro-3-(2,6-dichlorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 
• 1201837-07-1 3-[2-(2,6-dichloro-phenyl)-acetyl]-1-vinyl-pyrrolidin-2-one 
• 185039-76-3 6-(2,6-dichlorophenyl)-8-ethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 185039-46-7 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant academic research and scientific papers

MULTIPLE KINASE PATHWAY INHIBITORS

Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.

PROCESS FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENE

A production process for substituted phenylacetic acids or ester analogues thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.

Palladium-catalyzed oxidative carbonylation of benzylic C-H bonds via nondirected C(sp3)-H activation

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp3)-H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol for the oxidative carboxylation of benzylic C-H bonds to form substituted 2-phenylacetic acid esters and derivatives from inexpensive, commercially available starting materials.

Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors

A series of thiadiazole-based thioglycosides were synthesized as SGLT2 inhibitors from D-glucose, D-galactose and a variety of phenylacetic acids via a convenient protocol in 8 steps and evaluated in vivo with an oral glucose tolerance test (OGTT), and 5-benzyl-1,3,4-thiadiazol-2-yl 1-thio-β-D-glucopyranoside (1a) was the most efficacious to suppress the blood glucose excursion during OGTT.

Enantioselective Protonation of Samarium Enolates by a C2-Symmetric Chiral Diol

High enantioselectivity (up to 97percentee) have been achieved in the protonation of samarium enolates which were generated by SmI2-mediated cross-coupling reaction between unsymmetrical dialkylketene and allyl iodide, using, using a C2-symmetr