907961-82-4

Basic information

• Product Name: 3-(4-amino-2-(phenylamino)thiazole-5-carbonyl)-2H-chromen-2-one
• Synonyms: 3-(4-amino-2-(phenylamino)thiazole-5-carbonyl)-2H-chromen-2-one
• CAS NO: 907961-82-4
• Molecular Weight: 363.397
• Mol File: 907961-82-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-amino-2-(phenylamino)thiazole-5-carbonyl)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-amino-2-(phenylamino)thiazole-5-carbonyl)-2H-chromen-2-one(907961-82-4)
• EPA Substance Registry System: 3-(4-amino-2-(phenylamino)thiazole-5-carbonyl)-2H-chromen-2-one(907961-82-4)

Safety Data

• Hazardous Substances Data: 907961-82-4(Hazardous Substances Data)

Upstream product

• 29310-88-1 3-bromoacetylcoumarin 
• 60093-30-3 4-phenyl-3-thio-allophanonitrile; sodium salt 
• 3949-36-8 3-acetylcoumarin 
• 103-72-0 phenyl isothiocyanate 
• 90223-75-9 1-(phenyl-3-(N-nitroguanidine))thiourea 

Relevant articles and documents

Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety

A series of new coumarin-containing compounds 3a-l and 4a-c was designed and synthesized based on the chalcone-type 4-amino-5-cinnamoylthiazole scaffold 2, and screened for their in vitro anticancer and antioxidant activities. Representatively, the 2-thiomorpholinothiazole derivative 3k with IC50 values of 7.5–16.9 μg/ml demonstrated good cytotoxic effects against tested cell lines MCF-7, HepG2 and SW480. Further investigation by flow cytometric analysis confirmed that this compound induces apoptotic cell death in MCF-7 cells and cause G1-phase arrest in the cell cycle. Moreover, most of compounds had intrinsic potential for radical scavenging activity and ferric-reducing power as investigated by DPPH and FRAP assays.