907970-33-6

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 57735-10-1 4-amino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 

Downstream Products

• 1356906-30-3 1-acetyl-3-phenyl-4-(2-thienylmethylenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one 

Relevant academic research and scientific papers

InVitro antioxidant activities of new 4,5-dihydro-1H-1,2,4-triazol-5-ones having thiophene ring with their acidic properties

Seven new 3-alkyl(aryl)-4-(2-thienymethylenamino)-4,5-dihydro- 1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)- 4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with thiophene-2-carbaldehyde. In addition, N-acetyl derivatives of compounds 2d-2g were also prepared. The structures of eleven new compounds synthesized were determined by elemental analysis as well as IR, NMR and UV spectral data. In addition, compounds 2a-g and 3a, 3b, 3d-f were also screened for their antioxidant activities and 2a-g were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four nonaqueous solvents (isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethyl formamide). Also half-neutralization potential values and the corresponding pKa values were determined in all cases. Copyright E-Journal of Chemistry 2004-2011.