908003-47-4

Upstream product

• 111060-52-7 (S)-2-(dibenzylamino)-3-phenylpropan-1-ol 
• 100-39-0 benzyl bromide 
• 133522-38-0 (S)-2-Amino-1-benzylethanol 
• 1187326-72-2 (R)-1-benzylamino-3-phenylpropan-2-ol 

Relevant academic research and scientific papers

Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol.

Highly enantioselective synthesis of β-amino alcohols: A catalytic version

(Chemical Equation Presented) Highly enantioselective rearrangement of β-amino alcohols was realized by using a catalytic amount of trifluoroacetic anhydride.

Stereospecific rearrangement of β-amino alcohols catalyzed by H 2SO4

Highly enantioselective rearrangement of β-amino alcohols was realized by using a catalytic amount of H2SO4. Georg Thieme Verlag Stuttgart.

Highly enantioselective synthesis of β-amino alcohols

N,N-Dialkyl-β-amino alcohols derived from α-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.