908005-99-2

Basic information

• Product Name: 2-amino-5-iodo-3-methyl-benzoic acid ethyl ester
• Synonyms: 2-amino-5-iodo-3-methyl-benzoic acid ethyl ester
• CAS NO: 908005-99-2
• Molecular Weight: 305.115
• Mol File: 908005-99-2.mol

Chemical Properties

• CAS DataBase Reference: 2-amino-5-iodo-3-methyl-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-iodo-3-methyl-benzoic acid ethyl ester(908005-99-2)
• EPA Substance Registry System: 2-amino-5-iodo-3-methyl-benzoic acid ethyl ester(908005-99-2)

Safety Data

• Hazardous Substances Data: 908005-99-2(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 108857-24-5 2-amino-5-iodo-3-methylbenzoic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 908006-00-8 ethyl 2-({3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}amino)-5-iodo-3-methylbenzoate 

Relevant articles and documents

Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors

Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly improved the pharmacokinetic profile in the cynomolgus monkey compared with 1. Additional SAR studies aimed at improving the solubility of 9 are also described.

2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES

There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable solvates thereof.