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4-[(3-cyanophenyl)amino]-8-methyl-6-(methylsulfonyl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

908006-13-3

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908006-13-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 908006-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,0,0 and 6 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 908006-13:
(8*9)+(7*0)+(6*8)+(5*0)+(4*0)+(3*6)+(2*1)+(1*3)=143
143 % 10 = 3
So 908006-13-3 is a valid CAS Registry Number.

908006-13-3Downstream Products

908006-13-3Relevant academic research and scientific papers

Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors

Lunniss,Eldred,Aston,Craven,Gohil,Judkins,Keeling,Ranshaw,Robinson,Shipley,Trivedi

scheme or table, p. 137 - 140 (2010/04/26)

Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly improved the pharmacokinetic profile in the cynomolgus monkey compared with 1. Additional SAR studies aimed at improving the solubility of 9 are also described.

2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES

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Page/Page column 2; 20 - 21, (2008/06/13)

There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable solvates thereof.

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