908010-83-3Relevant academic research and scientific papers
Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: Impacting hERG liability via aryl modifications
McBriar, Mark D.,Guzik, Henry,Shapiro, Sherry,Xu, Ruo,Paruchova, Jaroslava,Clader, John W.,O'Neill, Kim,Hawes, Brian,Sorota, Steve,Margulis, Michael,Tucker, Kristal,Weston, Daniel J.,Cox, Kathleen
, p. 4262 - 4265 (2006)
Herein, we report the discovery of an effective strategy to modulate liabilities related to affinity of previously disclosed bicyclohexane MCHR-1 antagonists for the hERG channel. This paper describes one of several strategies incorporated to limit hERG b
