Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: Impacting hERG liability via aryl modifications

DOI: 10.1016/j.bmcl.2006.05.069

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4262 - 4265 (2006)

Update date:2022-07-31

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Authors:

McBriar, Mark D.

Guzik, Henry

Shapiro, Sherry

Xu, Ruo Xu, Ruo

Paruchova, Jaroslava

Clader, John W.

O'Neill, Kim

Hawes, Brian

Sorota, Steve

Margulis, Michael

Tucker, Kristal

Weston, Daniel J.

Cox, Kathleen

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Article abstract of DOI:10.1016/j.bmcl.2006.05.069

Herein, we report the discovery of an effective strategy to modulate liabilities related to affinity of previously disclosed bicyclohexane MCHR-1 antagonists for the hERG channel. This paper describes one of several strategies incorporated to limit hERG b

Full text of DOI:10.1016/j.bmcl.2006.05.069

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