Bioorganic and Medicinal Chemistry Letters p. 4262 - 4265 (2006)
Update date:2022-07-31
Topics:
McBriar, Mark D.
Guzik, Henry
Shapiro, Sherry
Xu, Ruo
Paruchova, Jaroslava
Clader, John W.
O'Neill, Kim
Hawes, Brian
Sorota, Steve
Margulis, Michael
Tucker, Kristal
Weston, Daniel J.
Cox, Kathleen
Herein, we report the discovery of an effective strategy to modulate liabilities related to affinity of previously disclosed bicyclohexane MCHR-1 antagonists for the hERG channel. This paper describes one of several strategies incorporated to limit hERG b
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