90812-66-1

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(CarboxyMethoxy)-benzoic acid Methyl ester is used as a precursor in the synthesis of pharmaceuticals and other organic compounds. Its unique structure and reactivity make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
In the field of organic chemistry, 4-(CarboxyMethoxy)-benzoic acid Methyl ester is used as a versatile building block for the creation of new compounds. Its ability to participate in various chemical reactions allows researchers to explore its potential in the synthesis of complex organic molecules.
Used in Chemical Reactions:
4-(CarboxyMethoxy)-benzoic acid Methyl ester is utilized in various chemical reactions due to its stability and reactivity. This makes it a valuable component in the synthesis of a wide range of organic compounds, contributing to the advancement of organic chemistry and the development of novel materials.

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 79-11-8 chloroacetic acid 
• 35005-30-2 methyl 4-(2-methoxy-2-oxoethoxyl)benzoate 
• 79-08-3 bromoacetic acid 
• 174666-21-8 4-t.-butoxycarbonylmethoxy-benzoic acid methyl ester 
• 19360-67-9 4-carboxymethoxy-benzoic acid 

Downstream Products

• 1256258-89-5 methyl 4-(2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yloxy)benzoate 
• 1096091-38-1 methyl 4-(2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)-2-oxoethoxy)benzoate 

Relevant academic research and scientific papers

Non-steroidal anti-inflammatory agents. Part 23: Synthesis and pharmacological activity of enaminones which inhibit both bovine cyclooxygenase and 5-lipoxygenase

The synthesis and stereochemical characteristics of pyrrolidino-, isoquinolino- and indolo-enaminones 2-11 are reported. The inhibition of cyclooxygenase was determined in a bovine thrombocyte intact cell assay and that of 5-lipoxygenase using intact bovine polymorphonuclear leucocytes. Except compound 2c′ which is a well-balanced dual inhibitor of both enzymes, all other enaminone derivatives are weak inhibitors of both cyclooxygenase and 5-lipoxygenase. Structure-activity relationships of the enaminones in relation to known anti-inflammatory drugs are discussed. Johann Ambrosius Barth 1998.

Aryl alkyl ether compound as well as derivative, preparation method, pharmaceutical composition and application thereof

The invention discloses an aryl alkyl ether compound as well as a derivative, a preparation method, a pharmaceutical composition and application thereof. The structure of the aryl alkyl ether compound is shown as a formula (I). The aryl alkyl ether compound derivative relates to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the stereoisomer, the tautomer, the metabolite, the metabolic precursor, the prodrug and the solvate of the aryl alkyl ether compound. The aryl alkyl ether compound and the derivative thereof have a remarkable inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing a medicine for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, and the prepared medicine can exert the medicine effect at the molecular level and is wide in application.

BENZODICYCLOALKANE DERIVATIVE, PREPARATION METHOD AND USE THEREOF

It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.

Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.

Triazole derivatives

The present invention relates to triazole and imidazole derivatives of formula I and to their pharmaceutically acceptable acid addition salts. These compounds are NMDA receptor subtype blockers and are useful for the treatment of diseases related to the NMDA receptor.

Use of Phosphorus Pentoxide. Preparation of Half-esters through Selective Esterification

Methyl 2-,3-,4-carboxyphenylacetate and methyl 2-,3-,4-carboxyphenoxyacetate have been prepared through selective esterification of the aliphatic carboxylic acid function of the corresponding dicarboxylic acids using a mixture of phosphorus pentoxide (1 part), anhydrous copper sulphate (5 parts) and anhydrous sodium sulphate (5 parts).All the isomeric half-esters have been prepared through partial hydrolysis of the corresponding dimethylesters.