90817-34-8

Basic information

• Product Name: 2-Methylamino-3-amino-6-methoxypyridine
• Synonyms: 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL;2-METHYLAMINO-3-AMINO-6-METHOXYPYRIDINE HCL;2-Methylamino-3-amino-6-methoxypyridine;2,3-Pyridinediamine, 6-methoxy-N2-methyl-;6-METHYLAMINO-3-AMINO-6-METHOXYPYRIDINE HYDROCHLORIDE;HCBLUENO7;ICOTINALDEHYDE;6-Methoxy-N2-Methylpyridine-2,3-diaMine
• CAS NO: 90817-34-8
• Molecular Formula: C7H11N3O
• Molecular Weight: 153.18
• EINECS: 207-900-4
• Mol File: 90817-34-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 78-81 °C10 mm Hg(lit.)
• Flash Point: 140 °F
• Appearance: clear brown-yellow/liquid (clear)
• Density: 1.141 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.000495mmHg at 25°C
• Refractive Index: n20/D 1.549(lit.)
• Storage Temp.: 2-8°C
• PKA: pK1:3.80(+1) (25°C)
• CAS DataBase Reference: 2-Methylamino-3-amino-6-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylamino-3-amino-6-methoxypyridine(90817-34-8)
• EPA Substance Registry System: 2-Methylamino-3-amino-6-methoxypyridine(90817-34-8)

Safety Data

• Hazard Codes: Xi
• Statements: 10-37/38
• Safety Statements: 26-39
• RIDADR: UN 1989 3/PG 3
• WGK Germany: 3
• RTECS: QS2980000
• F: 8-10-23
• Hazardous Substances Data: 90817-34-8(Hazardous Substances Data)

Usage

Contact allergens

This substance, with EINECS Nr. 280-622-10, is used in two component (oxidation) hair dyes.

InChI:InChI=1/C7H11N3O/c1-9-7-5(8)3-4-6(10-7)11-2/h3-4H,8H2,1-2H3,(H,9,10)

Upstream product

• 33742-70-0 6-chloro-N-methyl-3-nitropyridin-2-amine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 94166-58-2 6-methoxy-2-methylamino-3-nitropyridine 

Downstream Products

• 172648-25-8 5-[4-(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione 

Relevant articles and documents

Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones

A series of imidazopyridine thiazolidine-2,4-diones were designed and synthesized from their corresponding pyridines. These compounds represent conformationally restricted analogues of the novel hypoglycemic compound rosiglitazone (5). The series was evaluated for its effect on insulin-induced 3T3-L1 adipocyte differentiation in vitro and its hypoglycemic activity in the genetically diabetic KK mouse in vivo. The structure-activity relationships are discussed. On the basis of the in vivo potency, 5-[4-(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)ben zyl]thiazolidine-2,4-dione (19a) was selected as the candidate for further studies in a clinical setting.