908239-29-2Relevant academic research and scientific papers
Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site
Montalban, Antonio Garrido,Boman, Erik,Chang, Chau-Dung,Ceide, Susana Conde,Dahl, Russell,Dalesandro, David,Delaet, Nancy G.J.,Erb, Eric,Ernst, Justin T.,Gibbs, Andrew,Kahl, Jeffrey,Kessler, Linda,Kucharski, Jeff,Lum, Christopher,Lundstr?m, Jan,Miller, Stephen,Nakanishi, Hiroshi,Roberts, Edward,Saiah, Eddine,Sullivan, Robert,Urban, Jan,Wang, Zhijun,Larson, Christopher J.
, p. 4819 - 4824 (2010)
We have optimized a novel series of potent p38 MAP kinase inhibitors based on an α-ketoamide scaffold through structure based design that due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADM
