908241-76-9

Upstream product

• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 56632-83-8 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine 
• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 128495-99-8 1-(3,5-O-dibenzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine 
• 908241-70-3 N-{1-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 908241-68-9 5'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-fluoroarabinocytidine 
• 4301-14-8 acetylenemagnesium bromide 

Relevant academic research and scientific papers

Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosides

1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)uracil (5) and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine (6) were synthesized as reported earlier. Both of these compounds were converted into 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D- lyxofuranosyl nucleosides (16-19) by a multistep sequence. All these new nucleosides were evaluated against seven human tumor cell lines in vitro. Copyright Taylor & Francis, Inc.