Nucleosides, nucleotides and nucleic acids p. 713 - 715 (2005)
Update date:2022-08-03
Topics:
Moukha-Chafiq
Tiwari
Secrist III
1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)uracil (5) and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine (6) were synthesized as reported earlier. Both of these compounds were converted into 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D- lyxofuranosyl nucleosides (16-19) by a multistep sequence. All these new nucleosides were evaluated against seven human tumor cell lines in vitro. Copyright Taylor & Francis, Inc.
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