908306-41-2Relevant academic research and scientific papers
QUINAZOLINE DERIVATIVE HAVING TYROSINE KINASE INHIBITORY ACTIVITY
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Page/Page column 79-80, (2008/06/13)
A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof or a solvate of the compound or the salt: (I) wherein Rx represents a group represented by the formula(II): where R1 represents a hydrogen atom, an alkyl group which may be substituted or the like, Z represents -O-, -N(R10)- or the like, R10 represents a hydrogen atom, an alkyl group or the like, R2 represents a hydrogen atom, an alkyl group which may be substituted or the like, R18 represents a hydrogen atom, an alkyl group which may be substituted or the like, R19 represents an alkyl group which may be substituted or the like, W1 represents a non-aromatic nitrogenated heterocyclic group which may be substituted, and R17 represents a hydrogen atom, an alkyl group which may be substituted or the like; R3 and R4 independently represent a hydrogen atom, an alkyl group which may be substituted or the like; X represents -O-, -S-, -N(R12)- or the like; R12 represents a hydrogen atom, an alkyl group or the like; and A represents a phenyl group which may be substituted or the like. The compound can inhibit both EGF receptor tyrosine kinase and HER2 tyrosine kinase.
