90834-05-2

Basic information

• Product Name: 1-Pentanone, 1-(2,4,5-trimethoxyphenyl)-
• CAS NO: 90834-05-2
• Molecular Formula: C14H20O4
• Molecular Weight: 252.31
• Mol File: 90834-05-2.mol

Chemical Properties

• CAS DataBase Reference: 1-Pentanone, 1-(2,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanone, 1-(2,4,5-trimethoxyphenyl)-(90834-05-2)
• EPA Substance Registry System: 1-Pentanone, 1-(2,4,5-trimethoxyphenyl)-(90834-05-2)

Safety Data

• Hazardous Substances Data: 90834-05-2(Hazardous Substances Data)

Upstream product

• 2082-59-9 pentanoic anhydride 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 638-29-9 n-valeryl chloride 
• 109-52-4 valeric acid 

Downstream Products

• 90834-08-5 α-bromo-2,4,5-trimethoxyvalerophenone 
• 366815-17-0 α-n-butyl-2,4,5-trimethoxybenzenemethanol 

Relevant articles and documents

A new efficient method for the preparation of intermediate aromatic ketones by Friedel–Crafts acylation

Abstract: As the most important method to prepare pharmaceutical and chemical intermediate aromatic ketones, Friedel–Crafts (F–C) acylation is used to seek a novel catalytic system which is imminently consistent with the concept of green chemistry. In this study, six deep eutectic solvents (DES) were synthesized for the Friedel–Crafts acylation reaction as a catalytic solvent. Among the six DES, choline chloride-zinc chloride ([ChCl][ZnCl2]2) proved to be the most competent candidate of electron-rich arenes with acylation reagent. It got the highest yield when 1.0 equivalent of [ChCl][ZnCl2]2 used with acyl halides at 70?°C. Recycled DES was reused directly without any extra process. After five cycles, the catalytic activity did not decrease significantly (80–85%). Finally, according to experimental validation, the possible mechanism of this reaction was considered. Graphical Abstract: [Figure not available: see fulltext.].

A mechanistic deviation in the Bischler indole synthesis

When α-bromo-2,4,5-trimethoxybutyrophenone reacted with p-toluidine, the unexpected 3,5-dimethyl-2-(2,4,5-trimethoxybenzyl)indole was obtained. This mechanistic deviation was also observed with α -bromo-2,4,5-trimethoxyvalerophenone and α -bromo-2,4,5-tri

Synthesis and hypolipidemic activity of modified side chain α-asarone homologues

A series of homologues of α-asarone (1), containing variable size and functionality on the side chain attached to the aromatic ring, has been subjected to a study of structure-activity relationship. For most of the prepared derivatives, either with a carbonyl (8a-8e), a hydroxy group (9a-9e), or with a conjugated double bond (10a-10d), significant effects on serum lipoprotein cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were displayed. The results showed an enhancement of the hypocholesterolemic activity as the length of the chain is decreased. Theoretical conformational and electrostatic potential analyses of 1 and olefins 10 suggest unfavorable steric interactions in the bulky superior side-chain homologues as the deactivating biological effect.