90838-85-0Relevant articles and documents
Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines
Fliege, Julian,Glorius, Frank,Heusler, Arne,Wagener, Tobias
supporting information, p. 13793 - 13797 (2021/05/13)
Dearomatization is an effective method to transform readily available N-heterocycles into partially saturated motifs. Manipulation of dihydro-derivatives holds great potential and provides access to a variety of semi-saturated N-heterocyclic building blocks. However, current strategies are limited in scope and the use of sensitive reagents restricts the applicability in synthetic laboratories. Herein, we report the synthesis of a broad variety of N-substituted 1,4- and 1,2-dihydropyridines by very mild and selective reduction with amine borane for the first time.