908567-91-9Relevant academic research and scientific papers
Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist
Koo, Ja Young,Oh, Sangmi,Cho, Seung-Rye,Koh, Minseob,Oh, Won-Keun,Choi, Hueng-Sik,Park, Seung Bum
, p. 5782 - 5786 (2013)
Total synthesis of eryvarin H and a biological investigation of its analogues as a potential inverse agonist of ERRγ are described here. Among the 13 analogues prepared by the modular synthetic route, eryvarin H and compound 12 showed meaningful ERRγ inverse agonistic activities along with moderate selectivity over ERα and other nuclear receptors in the cell-based reporter gene assay.
Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif
Ko, Sung Kon,Jang, Hwan Jong,Kim, Eunha,Park, Seung Bum
, p. 2962 - 2964 (2008/09/19)
A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity
