908568-01-4Relevant academic research and scientific papers
Novel benzopyranyl tetracycle compound and pharmaceutical composition having excellent anti-inflammatory effect comprising the same
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Paragraph 0064; 0073; 0078; 0079, (2019/09/05)
The present invention relates to a novel compound of chemical formula 3 or 5 and a pharmaceutical composition having an excellent anti-inflammatory effect comprising the same. The compounds inhibit the migration of HMGB1 protein, which is an inflammation-inducing factor, from nucleus to cytoplasm, thereby having an excellent inflammation-inhibiting effect, particularly having an excellent effect of treating or preventing septicemia and the like.COPYRIGHT KIPO 2019
Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents
Cho, Wansang,Koo, Ja Young,Park, Yeonju,Oh, Keunhee,Lee, Sanghee,Song, Jin-Sook,Bae, Myung Ae,Lim, Donghyun,Lee, Dong-Sup,Park, Seung Bum
, p. 170 - 179 (2017/04/26)
Sepsis is one of the major causes of death worldwide when associated with multiple organ failure. However, there is a critical lack of adequate sepsis therapies because of its diverse patterns of pathogenesis. The pro-inflammatory cytokine cascade mediate
Construction of polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway: Part II
Zhu, Mingyan,Lim, Byung Joon,Koh, Minseob,Park, Seung Bum
, p. 124 - 134 (2012/04/10)
As a continuation of our previous report (J. Comb. Chem.2010, 12, 548-558), we accomplished the diversity-oriented synthesis of polyheterocyclic small-molecule library with privileged benzopyran substructure. To ensure the synthetic efficiency, we utilized the solid-phase parallel platform and the fluorous-tag-based solution-phase parallel platform to construct a 284-member polyheterocyclic library with six distinct core skeletons with an average purity of 87% on a scale of 5-10 mg. This library was designed to maximize the skeletal diversity with discrete core skeletons in three-dimensional space and the combinatorial diversity with four different benzopyranyl starting materials and various building blocks. Together with our reported benzopyranyl library, we completed the construction of polyheterocyclic benzopyran library with 11 unique scaffolds and their molecular diversity was visualized in chemical space using principle component analysis (PCA).
Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand
Zhu, Mingyan,Kim, Myung Hee,Lee, Sanghee,Bae, Su Jung,Kim, Seong Hwan,Park, Seung Bum
supporting information; experimental part, p. 8760 - 8764 (2011/02/23)
A novel benzopyran-fused molecular framework 7ai was discovered as a specific inhibitor of RANKL-induced osteoclastogenesis using a cell-based TRAP activity assay from drug-like small-molecule libraries constructed by diversity-oriented synthesis. Its inhibitory activity was confirmed by in vitro evaluations including specific inhibition of RANKL-induced ERK phosphorylation and NF-κB transcriptional activation. 7ai can serve as a specific small-molecule modulator for mechanistic studies of RANKL-induced osteoclast differentiation as well as a potential lead for the development of antiresorptive drugs.
Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif
Ko, Sung Kon,Jang, Hwan Jong,Kim, Eunha,Park, Seung Bum
, p. 2962 - 2964 (2008/09/19)
A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity
