908600-70-4 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole-4-carboxylic acid, 5-fluorois used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure allows for the creation of novel drug candidates that can target specific biological pathways or receptors, potentially leading to the discovery of new treatments for various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Indole-4-carboxylic acid, 5-fluorois utilized as a precursor in the synthesis of bioactive compounds. These compounds can be used in the development of pesticides, herbicides, or other agrochemicals that help protect crops and enhance agricultural productivity.
Used in Medicinal Chemistry Research:
1H-Indole-4-carboxylic acid, 5-fluoroserves as a valuable research tool in medicinal chemistry. It can be used to study the structure-activity relationships of indole-based compounds, aiding in the design and optimization of new therapeutic agents with improved efficacy and selectivity.
Used in Drug Discovery:
As a building block in drug discovery, 1H-Indole-4-carboxylic acid, 5-fluorois employed to explore its potential as a lead compound for the development of new drugs. Its unique chemical properties may offer novel mechanisms of action or binding affinities, contributing to the advancement of pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 908600-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,6,0 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 908600-70:
(8*9)+(7*0)+(6*8)+(5*6)+(4*0)+(3*0)+(2*7)+(1*0)=164
164 % 10 = 4
So 908600-70-4 is a valid CAS Registry Number.
908600-70-4Relevant academic research and scientific papers
In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids
Schlosser, Manfred,Ginanneschi, Assunta,Leroux, Frederic
, p. 2956 - 2969 (2007/10/03)
All twelve indolecarboxylic acids 1-12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13-16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation ("metalation"), or from the bromo- or iodofluoroindoles 17-20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time trapped with carbon dioxide. In most, though not all cases, the nitrogen atom in the five-membered ring had to be protected by a trialkylsilyl group. Some of the bromo- or iodofluoroindoles (26 and 27) were successfully subjected to a basicity gradient-driven selective migration of the heavy halogen. An unexpected finding on the way to the target compounds were the rigorously site-selective metalation of the 5-fluoro-N-(trialkylsilyl)indole (14b; exclusive deprotonation of the 4-position). The fluoroindoles 13-16, although previously known, were accessed more conveniently from suitably substituted nitrobenzenes using the Bartoli or the Leimgruber-Batcho method. A new and very attractive indole synthesis was elaborated consisting of the ortho-lithiation of an N-acyl-protected aniline followed by ortho-formylation, Wittig chloromethylenation and base-catalyzed cyclization accompanied by dehydrochlorination. These five consecutive steps can be contracted to a convenient one-pot protocol. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
